Since upping fish oil we are seeing a histamine type reaction…itchy legs, red ears, early waking, the development of hives. Why is that and what should we do?

If this is occurring, my first consideration is that leaky gut is still present and a change from inulin to monthly rifaximin or monthly rifaximin to continuous rifaximin is needed. Until then, dual histamine blockage is a standard approach to controlling the symptoms. If breathing issues occur, stop the fish oil and consult a medical allergist.