After a few months of Monthly Rifaximin I am still not seeing any changes. What should I do?

Even with monthly rifaximin, some patients still will not show evidence of recovery, and this is because they are relapsing even before the next course of rifaximin has begun.   If a patient is not showing any improvement after three months of rifaximin, I start these patients on non-stop, twice daily, continuous rifaximin along with five minutes of daily vagus nerve stimulation. nThe children are relapsing rapidly because of slow intestinal motility, often from autonomic nervous system damage.  I believe that the addition of vagus nerve stimulation in the patient will help insure their intestinal motility can improve to the degree that continuous rifaximin can ultimately be discontinued.

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